I love this one...wasn't really one I grew up with, I was introduced to it via my parents subscription post-childhood. But it is definitely one of my faves. I mean, "Little 'publican Annie Liberal Decoder Ring?"
Good ol' Calvin and Hobbes. Besides reading these in the daily paper, my brother always got the books...I could read any of the strips whenever I felt like it.
Who didn't grow up with this family in real-time? Not as hilarious as some of the others, but very endearing in a Family Circus type of way...
Doonesbury, by Garry Trudeau
Ah, Doonesbury. This is how I kept up with politics and current events when the newspaper articles were bland and tired...
Dilbert, by Scott Adams
And of course, Dilbert. I would read it as a kid, but now that I officially spend half my work day in a cubicle, I get it. Ha.
What are your favorites?